Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists
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چکیده
منابع مشابه
Enadoline and Butorphanol: Evaluation of -Agonists on Cocaine Pharmacodynamics and Cocaine Self-Administration in Humans
Preclinical studies have demonstrated that -opioid agonists can attenuate the neurochemical and behavioral effects of cocaine that are related to its reinforcing efficacy, suggesting that -agonists may serve as pharmacotherapies for cocaine dependence. This 8-week inpatient study examined the ability of enadoline, a selective and high-efficacy -agonist, and butorphanol, a mixed agonist with int...
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Preclinical studies have demonstrated that kappa-opioid agonists can attenuate the neurochemical and behavioral effects of cocaine that are related to its reinforcing efficacy, suggesting that kappa-agonists may serve as pharmacotherapies for cocaine dependence. This 8-week inpatient study examined the ability of enadoline, a selective and high-efficacy kappa-agonist, and butorphanol, a mixed a...
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Cocaine addiction is a worldwide public health problem for which there are no established treatments. The dopamine transporter (DAT) is suspected as the primary target mediating cocaine's abuse-related effects based on numerous pharmacological studies. However, in a previous study, DAT knockout mice were reported to self-administer cocaine, generating much debate regarding the importance of the...
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1. Abstract 2. Introduction 3. Nucleus accumbens 4. Stimulant actions 4.1. Cocaine and amphetamine 4.2. In vitro brain slice voltammetry 4.3. Microdialysis 4.4. Differences in dopamine signaling within the nucleus accumbens 4.5. Time of onset of cocaine and other dopamine transporter inhibitors 5. Neurochemical consequences of cocaine and amphetamine self-administration 5.1. Reduced responsivit...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2012
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2012.224